FITC标记的螺旋一环一螺旋蛋白5抗体
产品名称： FITC标记的螺旋一环一螺旋蛋白5抗体
英文名称： Anti-BHLHB5/FITC
产品编号： HZ-11808R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-BHLHB5/FITC Conjugated antibody
FITC标记的螺旋一环一螺旋蛋白5抗体
| 产品编号 | bs-11808R-FITC |
| 英文名称 | Anti-BHLHB5/FITC |
| 中文名称 | FITC标记的螺旋一环一螺旋蛋白5抗体 |
| 别 名 | BETA 3; Basic helix loop helix protein 5; Beta3; BHE22_HUMAN; bHLHB5; bHLHe22; CAGL85; Class B basic helix-loop-helix protein 5; Class E basic helix-loop-helix protein 22; Class II bHLH protein BHLHB5; TNRC20; Trinucleotide repeat containing 20; Trinucleotide repeat-containing gene 20 protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BHLHB5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes. Class A proteins include the ubiquitously expressed E-box binding factors E12/E47, ITF2 and HEB (BETA 1 or HTF4). Class B proteins such as Myo D, myogenin and Neuro D (BETA 2) are transiently expressed and exhibit a more limited tissue distribution. Class A proteins heterodimerize with class B proteins to activate transcription. Working in opposition to these positively acting factors are a specialized group of proteins that function as dominant negative regulators. For instance, the Id family of transcriptional repressors contains a HLH region required for dimerization but lacks a functional DNA-binding domain. The Id family can therefore form heterodimers with the myogenic family, but the resulting complexes are transcriptionally inactive. BETA 3 is a protein that is functionally similar to members of the Id family in that it can inhibit the binding of E47 homodimers as well as E47/Neuro D and E47/Myo D heterodimers to consensus DNA sequences . In contrast to members of the Id family, BETA 3 contains a putative DNA-binding domain. Function: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA. Subcellular Location: Nucleus. Tissue Specificity: Brain-specific, with the highest expression in the cerebellum. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 27319 Human Entrez Gene: 59058 Mouse Entrez Gene: 365748 Rat Omim: 613483 Human SwissProt: Q8NFJ8 Human SwissProt: Q8C6A8 Mouse Unigene: 388788 Human Unigene: 591870 Human Unigene: 149938 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
肌源性决定族的成员是基本的螺旋-环-螺旋（BHLH）蛋白，可分为两类。A类蛋白包括E-box结合因子E12/E47、ITF2和HEB（β1或HTF4）。B类蛋白如MyoD、肌生成素和神经D（β2）瞬时表达并表现出更有限的组织分布。A类蛋白与B类蛋白异源二聚以激活转录。反对这些积极作用的因素是一组特殊的蛋白质，它们起主导的负调节作用。例如，Id家族的转录阻遏物包含二聚作用所需的HLH区域，但缺少功能性DNA结合结构域。因此，Id家族可以与myogenic家族形成异源二聚体，但是所得到的复合物是转录不活跃的。β3是一种功能类似于Id家族成员的蛋白质，因为它可以抑制E47同型二聚体以及E47 /神经D和E47／MYO D异源二聚体对一致DNA序列的结合。与Id家族成员相比，β3包含一个假定的DNA结合结构域。