Recombinant Human GM-CSF-细胞/细菌培养-试剂-生物在线
翌圣生物科技(上海)股份有限公司
Recombinant Human GM-CSF

Recombinant Human GM-CSF

商家询价

产品名称: Recombinant Human GM-CSF

英文名称: Recombinant Human GM-CSF

产品编号: 91102ES08

产品价格: 0

产品产地: Yeasen

品牌商标: Yeasen

更新时间: 2024-12-10T13:22:33

使用范围: null

翌圣生物科技(上海)股份有限公司
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 Product Information

 

Product Name

Cat#

Size

Price¥

Recombinant Human GM-CSF

91102ES08

5 μg

815.00

91102ES60

10μg

6815.00

91102ES76

500 μg

20425.00

91102ES80

1 mg

31625.00

 

Product Description

 

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is a powerful growth and differentiation factor which acts on hematopoietic progenitor cells and also activates differentiated granulocytes and macrophages. The 22 kDa glycosylated GMCSF, similar to IL3 and IL5, is a cytokine with a core of four bundled alpha -helices. Mature human GMCSF shares 63%70% amino acid sequence identity with canine, feline, porcine, and rat GMCSF and 54% with mouse GMCSF. GM-CSF has been and is still widely used as an adjuvant in clinical trials of vaccination with autologous tumor cells, peptides and/or dendritic cells in a variety of human neoplasms. The effects of GM-CSF on HIV-1 replication in primary monocytes and macrophages, and in related cell lines, have demonstrated augmentation of HIV-1 expression in vitro.

 

Product Properties

 

Synonyms

Granulocyte/Macrophage Colony-Stimulating Factor, GM-CSF, CSF-2, MGI-1GM, Pluripoietin-α

Accession

P04141

GeneID

1437

Source

E.coli-derived human GM-CSF proteinAla18-Glu144.

Molecular Weight

Approximately 14.5 kDa.

AA Sequence

APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQI ITFESFKENL KDFLLVIPFD CWEPVQE

Tag

None

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Purity

> 98% by SDS-PAGE and HPLC analyses.

Biological Activity

The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.1 ng/mL, corresponding to a specific activity of > 1.0 × 107 IU/mg. Fully biologically active when compared to standard.  

Endotoxin

< 1.0 EU per 1μg of the protein by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.

 

Shipping and Storage

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