FITC标记的环指蛋白47抗体
产品名称： FITC标记的环指蛋白47抗体
英文名称： Anti-RNF47/FITC
产品编号： HZ-6320R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-RNF47/FITC Conjugated antibody
FITC标记的环指蛋白47抗体
| 英文名称 | Anti-RNF47/FITC |
| 中文名称 | FITC标记的环指蛋白47抗体 |
| 别 名 | BAR; Bfar; BFAR_HUMAN; Bifunctional apoptosis inhibitor; Bifunctional apoptosis regulator; RING finger protein 47; RNF47. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Bifunctional apoptosis inhibitor |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Two converging apoptotic pathways, which are initiated either through the activation of death domain (DD) receptors by an extrinsic pathway or by an intrinsic pathway in the mitochondria, mediate the activation and progression of apoptosis within the cell. Both these pathways lead to the activation of the Serine proteinase cascade (caspases) and to cleavage of these pro-caspases. A novel protein, BAR, for bifunctional apoptosis regulator, contains domains that enable it to interact with components of both major apoptosis pathways, where it negatively regulates apoptotic signaling. Like the other anti-apoptosis proteins Bap31 and FLIP, BAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. In addition, BAR contains a domain that also enables it to interact with the mitochondrial Bcl-2 family of proteins. The presence of these various RING, SAM, DED and TM domains suggests that BAR may serve as a scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. Subunit: Interacts with CASP8, BCL2 and BCL2L1 through SAM domain and also with HIP1, IFT57, ESRRBL1 and BCAP31. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue Specificity: Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle. Not expressed in heart, kidney, lung and spleen. Similarity: Interacts with CASP8, Contains 1 RING-type zinc finger. Contains 1 SAM (sterile alpha motif) domain. Database links: Entrez Gene: 51283 Human Entrez Gene: 67118 Mouse Entrez Gene: 304709 Rat SwissProt: Q9NZS9 Human SwissProt: Q8R079 Mouse SwissProt: Q5PQN2 Rat Unigene: 435556 Human Unigene: 223689 Mouse Unigene: 159939 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Tissue specificity: Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle |
两个聚集的凋亡途径，通过激活死亡域（DD）受体，通过外源途径或线粒体内的固有途径，介导细胞内的凋亡的激活和进展。这两种途径都导致丝氨酸蛋白酶级联（caspase）的激活和这些亲胱天冬酶的裂解。一种新的蛋白质，bar，双功能细胞凋亡调节器，包含域，使其能够与主要凋亡途径的组成部分，其中负调节凋亡信号。与其他抗凋亡蛋白BAP31和FLIP一样，BAR含有能够抑制受体水平介导的细胞凋亡的类D结构域。此外，BAR包含一个域，它也使其能够与线粒体Bcl-2家族蛋白相互作用。这些不同的环、山姆、DD和TM域的存在提示BAR可以作为整合细胞凋亡调控机制的信号成分的支架蛋白。