E2F8,转录因子E2F8抗体

产品编号HZ-4265R
英文名称E2F8
中文名称转录因子E2F8抗体
别 名E2F 8; E2F family member 82; E2F transcription factor 8; E2F-8; E2f8; E2F8_HUMAN; FLJ23311; Transcription factor E2F8.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 染色质和核信号 信号转导 转录调节因子 新陈代谢 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit,
E2F8,转录因子E2F8抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量94kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human E2F8 (285-326aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
E2F8,转录因子E2F8抗体PubMedPubMed
产品介绍background:
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012].

Function:
Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.

Subunit:
Forms heterodimers with E2F7 and, to a lesser extent, homodimers. Dimerization is important for DNA binding.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the E2F/DP family

Gene ID:
79733

Database links:
Entrez Gene: 79733 Human
Entrez Gene: 108961 Mouse
Entrez Gene: 308607 Rat
Omim: 612047 Human
SwissProt: A0AVK6 Human
SwissProt: Q58FA4 Mouse
Unigene: 523526 Human
Unigene: 240566 Mouse
Unigene: 395068 Mouse

E2F8,转录因子E2F8抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.