Recombinant Porcine Interleukin-8/CXCL8 (Porcine IL-8/CXCL8)-细胞/细菌培养-试剂-生物在线
翌圣生物科技(上海)股份有限公司
Recombinant Porcine Interleukin-8/CXCL8 (Porcine IL-8/CXCL8)

Recombinant Porcine Interleukin-8/CXCL8 (Porcine IL-8/CXCL8)

商家询价

产品名称: Recombinant Porcine Interleukin-8/CXCL8 (Porcine IL-8/CXCL8)

英文名称: Recombinant Porcine Interleukin-8/CXCL8 (Porcine IL-8/CXCL8)

产品编号: 90903ES10

产品价格: 0

产品产地: Yeasen

品牌商标: Yeasen

更新时间: 2024-12-10T13:22:33

使用范围: null

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    Product Information

     

    Product Name

    Cat#

    Size

    Price¥

    Recombinant Porcine Interleukin-8/CXCL8 (Porcine IL-8/CXCL8)

    90903ES10

    10 μg

    2,215

    90903ES60

    100 μg

    7,865

    90903ES76

    500 μg

    20,425

     

    Product Description

     

    Interleukin-8 (IL-8), also known as CXCL8, GCP-1, and NAP-1, is a widely expressed proinflammatory member of the CXC family of chemokines. This 8-9 kDa chemokine circulates as a monomer, homodimer, and heterodimer with CXCL4/PF4. Its oligomerization is modulated by interactions with matrix and cell surface glycosaminoglycans (GAGs). Mature porcine CXCL8 shares 82%, 78%, and 65% amino acid (aa) sequence identiity with canine, feline, and human CXCL8. There is no CXCL8 gene counterpart in rodent. N-terminal truncation of CXCL8 by multiple proteases generates a range of shorter forms. The bioactivity of CXCL8 is regulated by these truncations and also by CXCL8 citrullination. CXCL8 effects are mediated through CXCR1/IL-8 RA, which is also used by CXCL6, and through CXCR2/IL-8 RB, which is used by multiple CXC chemokines. These receptors associate into functional homodimers and heterodimers with each other. Through both CXCR1 and CXCR2, CXCL8 promotes neutrophil adhesion to the vascular endothelium and migration to sites of inflammation. It triggers the antimicrobial activation of neutrophils through CXCR1. CXCL8 also binds to Serpin A1/alpha-1 Antitrypsin, and this prevents CXCL8 interaction with CXCR1. CXCL8 is up-regulated in atherosclerotic lesions and other cardiac pathologies where it exacerbates inflammatory tissue damage. In addition, it induces VEGF expression, vascular endothelial cell proliferation, angiogenesis, and tumor cell invasiveness.

     

    Product Properties

     

    Synonyms

    (Ser-IL-8)72, GCP/IL-8 protein I, IL8/NAP1 form III, LYNAP, MDNCF-c, NAF

    Accession

    P26894

    GeneID

    396880

    Source

    E.coli-derived Porcine IL-8/CXCL8Ala26-Gln103.

    Molecular Weight

    Approximately 9.1 kDa.

    AA Sequence

    ARVSAELRCQ CINTHSTPFH PKFIKELRVI ESGPHCENSE IIVKLVNGKE VCLDPKEKWV QKVVQIFLKR TEKQQQQQ

    Tag

    None

    Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

    Purity

    > 95% by SDS-PAGE and HPLC analyses.

    Biological Activity

    The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 20-200 ng/mL. Fully biologically active when compared to standard.

    Endotoxin

    1.0 EU per 1μg of the protein by the LAL method.

    Formulation

    Lyophilized from a 0.2 μm filtered concentrated solution in 2 × PBS, pH 7.4.

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.


    Shipping and Storage

     

    The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

    Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

     

    Cautions

     

    1. Avoid repeated freeze-thaw cycles.

    2. For your safety and health, please wear lab coats and disposable gloves for operation.

    3. For research use only!

     

    HB220425