FITC标记的锚定蛋白G抗体
产品名称： FITC标记的锚定蛋白G抗体
英文名称： Anti-Ankyrin G/FITC
产品编号： HZ-2415R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Ankyrin G/FITC Conjugated antibody
FITC标记的锚定蛋白G抗体
| 英文名称 | Anti-Ankyrin G/FITC |
| 中文名称 | FITC标记的锚定蛋白G抗体 |
| 别 名 | ANK-3; ANK-3; ANK3; ANK3_HUMAN; ankyrin 3 (G); Ankyrin 3, node of Ranvier (ankyrin G); Ankyrin 3, node of Ranvier; Ankyrin G119; Ankyrin-3; Ankyrin-G; brain specific ankyrin G; CHANK3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 细胞粘附分子 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 481/220kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Ankyrin G |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: human: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple transcript variants encoding several different isoforms have been found for this gene, the full-length nature of only two have been characterized. [provided by RefSeq] mouse: This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Function: In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Subunit: Directly interacts with DMD and betaDAG1. This interaction does not interfere with binding between DMD and betaDAG1. It is also required for DMD and betaDAG1 retention at costameres (By similarity). Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 5 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). May be a constituent of a neurofascin/NRCAM/ankyrin G complex. Interacts with RHBG. Subcellular Location: Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane (By similarity). Lysosome (By similarity). Note=In skeletal muscle, localized at costameres and neuromuscular junctions (By similarity). In macrophages, associated with lysosomes (By similarity). Tissue Specificity: Expressed in brain, neurons and other tissues. DISEASE: Note=Genetic variations in ANK3 are associated with autism spectrum disorders susceptibility. Similarity: Contains 23 ANK repeats. Contains 1 death domain. Contains 2 ZU5 domains. Database links: Entrez Gene: 288 Human Entrez Gene: 11735 Mouse Entrez Gene: 361833 Rat Omim: 600465 Human SwissProt: Q12955 Human SwissProt: G5E8K5 Mouse SwissProt: Q4U206 Mouse Unigene: 499725 Human Unigene: 235960 Mouse Unigene: 202383 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 锚定蛋白G是一个分子量在480KDa大分子细胞内蛋白。 锚蛋白(ankyrin)锚蛋白属于联结蛋白家族,广泛存在于各种组织细胞中。锚蛋白连接整合膜蛋白到细胞骨架蛋白网络,在多种细胞功能活动中起关键作用,参与机体生长、发育、细胞内蛋白转运、细胞极性的建立和维持、细胞黏附、信号传导以及mRNA转录等 |
人类：锚蛋白是一种蛋白质家族，被认为将完整的膜蛋白与底层的光谱学肌动蛋白细胞骨架联系起来，并在诸如细胞运动、活化、增殖、接触和维持专门的膜结构域等活动中起关键作用。具有不同亲和力的锚蛋白的多个异构体以不同的靶蛋白表达，以组织特异性、发育调节的方式表达。大多数锚蛋白通常由三个结构域组成：含有多个锚蛋白重复序列的氨基末端结构域；具有高度保守的谱蛋白结合结构域的中心区域；和羧基末端调节域，该保守域是保守的，且可能发生变异。锚蛋白3是来自于1和2的强直性免疫基因产物，最初发现于中枢和外周神经系统神经元的轴突起始节段和淋巴结。另外，剪接变异体可以在其他组织中表达。虽然已经发现了编码该基因的几种不同的异构体的多个转录变体，但仅有两个全长的性质已经被表征。[由RefSeq提供]
小鼠：该基因编码锚蛋白家族的一员。锚蛋白将完整的膜蛋白连接到基于血影蛋白的锚蛋白上，将完整的膜蛋白连接到基于血影素的细胞骨架上。Ankyrin家族成员共有一个蛋白质结构，包括三个独立折叠的结构域：N-末端锚蛋白重复结构域、中心血影结合结构域和C-末端杆结构域。锚蛋白在肾脏中起着重要的锚蛋白作用，并可能在许多整合膜蛋白向特定亚细胞部位的极化分布中起作用。该基因的选择性剪接导致编码不同亚型的多个转录变体。