NUFIP1抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
NUFIP1抗体

NUFIP1抗体

商家询价

产品名称： NUFIP1抗体

英文名称： NUFIP1Antibody

产品编号： XY12515-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 NUFIP1抗体Applications

In-house applications ELISA, WB, IHC, IP     Application not tested? Please see our Guarantee.
Published applications PLA (proximity ligation assay), WB Publications 3 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 12515-1-AP;A375 cellsA375 cells were subjected to SDS PAGE followed by western blot with 12515-1-AP(NUFIP1 antibody) at dilution of 1:400
  • 12515-1-AP;human ovary tumorImmunohistochemical of paraffin-embedded human ovary tumor using 12515-1-AP(NUFIP1 antibody) at dilution of 1:50 (under 10x lens)
  • 12515-1-AP;HeLa cellsIP Result of anti-NUFIP1 (IP:12515-1-AP, 4ug; Detection:12515-1-AP 1:800) with HeLa cells lysate 1200ug.
Positive WB detected in A375 cells, HeLa cells
Positive IP detected in HeLa cells
Positive IHC detected in Human ovary tumor tissue
Recommended dilution WB : 1:500-1:5000
IP : 1:200-1:2000
IHC : 1:20-1:200
 NUFIP1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information NUFIP1抗体
Immunogen NUFIP1 fusion protein ag3197 Full name Nuclear fragile X mental retardation protein interacting protein 1
Calculated molecular
weight		 56 kDa Observed molecular 
weight		 70-75 kDa
GenBank accession 
number		 BC017745 Gene ID (NCBI) 26747
Gene symbol NUFIP1 Synonyms BA540M5.1, NUFIP, NUFIP1
Background

Fragile X syndrome, the most common cause of inherited mental retardation, is caused by the absence of FMRP (Fragile X Mental Retardation Protein). FMRP is an RNA binding protein reported to be involved in translational control, notably at postsynaptic sites of protein synthesis as a part of a multiprotein/mRNA complex[PMID:12941608]. NUFIP1 is one of the several FMRP-interacting proteins. NUFIP can act as a pol II-specific basal transcriptional activator in vitro and when ectopically overexpressed in vivo. NUFIP can directly activate promoters by enhancing the ATP-dependent release of hyperphosphorylated form of pol II from open transcription complexes[PMID:15107825]. NUFIP1抗体

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