FITC标记的21号染色体开放阅读框33抗体
产品名称： FITC标记的21号染色体开放阅读框33抗体
英文名称： Anti-C21orf33/FITC
产品编号： HZ-15124R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-C21orf33/FITC Conjugated antibody
| FITC标记的21号染色体开放阅读框33抗体 |
| 英文名称 | Anti-C21orf33/FITC |
| 中文名称 | FITC标记的21号染色体开放阅读框33抗体 |
| 别 名 | Chromosome 21 open reading frame 33; D21S2048E; ES 1; ES1; Es1 protein; ES1 protein homolog mitochondrial; GT335; HES 1; HES1; Human HES1 protein homolog to E.coli and zebrafish ES1 protein; Keio novel protein I; KNP I; KNPH; KNPI; Protein GT335; Protein KNP I; ES1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C21orf33 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: KNP-I is a ubiquitously expressed mitochondrial protein that belongs to the ES1 family of proteins. It is a highly conserved protein with homologs identified in various species. This conserved nature suggests an important biological role for the KNP-I protein. The gene that encodes KNP-I (C21orf33) is located on human chromosome 21 in close proximity to a region (D21S25) associated with many genetic diseases. Down syndrome (DS), caused by an extra copy of chromosome 21, is the most common manifestation of trisomic chromosomes. It is likely that the overproduction of the C21orf33 gene product plays a role in the pathology of DS, while its chromosomal location suggests its likely involvement in D21S25 related diseases. While expressed in most tissue, highest expression of KNP-I is found in heart and muscle Subcellular Location: Mitochondrion (Potential). Tissue Specificity: Ubiquitous, but strongly expressed in heartand skeletal muscle. Similarity: Belongs to the ES1 family. Database links: Entrez Gene: 8209 Human Omim: 601659 Human SwissProt: P30042 Human Unigene: 413482 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
KNP-Ⅰ是一种广泛表达的线粒体蛋白，属于蛋白质ES1家族。它是一种高度保守的蛋白质，其同源物在各种物种中被鉴定。这种保守的性质表明KNP-Ⅰ蛋白具有重要的生物学作用。编码KNP-I(C21orf33)的基因位于人类21号染色体上，与许多遗传病相关的区域(D21S25)非常接近。由21号染色体的额外拷贝引起的唐氏综合征（DS）是三体染色体最常见的表现形式。C21orf33基因产物的过度产生可能在DS的病理过程中起作用，而它的染色体位置表明它可能参与了D21S25相关疾病。在大多数组织中，KNP-Ⅰ在心脏和肌肉中最高表达。